Yes, it can be done. Check out this mucho helpful article from CliqueclackTV on various types of interweb video series and how to start them:
Tired of TV? Create your own web series! – Monthly Musings
by An Nicholson
Although I think today’s TV is pretty good, it can improve. If you aren’t satisfied with network/cable shows, create your own! With today’s inexpensive technology and the multiple opportunities available through the internet, public access TV, campus TV, and local radio, you have NO excuse to NOT contribute to the creative TV landscape.
To provide suggestions for the fledgling web creator or student producer, I tapped the awesome Joe Wilson, writer/director of the kickbutt web series Vampire Mob and our own Katie Schenkel, who runs the movie review vlog, Just Plain Something.